Theme « modeling and simulation »

Researchers :

Guy Barles, Christine Georgelin, Jean-René Licois, Masoomeh Taghipoor.

Presentation:

This is a new activity for the LMPT laboratory, following the CASCIMODOT research project (Scientific Computing and Modeling in the Universities of Orléans and Tours) whose objective is to promote encounters and collaborations between different actors of modeling or scientific computing.

We develop two multi-disciplinary projects at LMPT:

TempoGnRH Project: collaboration between A. Duittoz (PRC INRA UMR085 CNRS UMR6175, MiDyNNet team) and C. Georgelin (LMPT), it is in the field of neuroscience. Begun in 2007, its initial aim was to analyze intracellular calcium signals in an appropriate way allowing to analyse the global behaviour of a neuronal network as well as individual neuronal activity.

The ultimate goal of the project is to develop a mathematical model ( TempoGnRH) which describes how the GnRH neurons network works globally (neurons and associated glial cells); it should be based on the close correlation demonstrated experimentally by A. Duittoz and her team, between GnRH neurosecretory episodes and synchronization of intracellular calcium changes between GnRH neurones.

Several presentations were held during the ''Journées Cascimodot Orléans-Tours''. Two posters were presented, one at the Congress of the National Society of Endocrinology in September 2009 in Nice, the other at the International Congress of Neuroendocrinology, held in Rouen in July 2010.

The MODINGRE Project (modeling of the small intestine), whose objective is to understand the phenomena of digestion (transport and degradation of the bolus) in this part of the intestine . It is part of a PEPS CNRS-INRA "Understanding and Modeling the fate of food in the gut". "

This project was jointly launched by Philippe Lescoat (INRA Nouzilly) and G. Barles, Ch. Georgelin and J.-R. Licois in 2007. It now includes teams from the INRA Clermont, Jouy-en-Josas, Nantes, Paris, Saint-Gilles (near Rennes).

After a first model based on partial differential equations, we have built several more realistic models based on systems of ordinary differential equations. The variables are the position and composition of bolus. Our present research consists in modeling the transport and the enzymatic actions not only inside the bolus but also on the intestinal wall by taking into account the effects of water. The experimental datas show that the presence of water affects the velocity of bolus in the small intestine as well as the absorption of produced nutrients by intestinal wall. Click here to access the project pages